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This is because it binds to the same receptors as ghrelin (known as GHSR-1a receptors) and increases the amount of GH and IGF-1 thats secreted while reducing the amount of somatostatin, a GH-inhibiting hormone [3]

The ghrelin pathway represents an alternative regulatory mechanism for growth hormone secretion

Mechanistic insights into the role of GH and IGF-I secretion in age-related alterations in cognitive function were assessed in several preclinical studies by Sonntag and colleagues, demonstrating somatotropic effects on rodent brain aging (31)

This is one reason cycling remains important

Both have a wealth of scientific support for their efficacy, but tirzepatide has a bit more evidence behind it

GH & IGF-1 support Studied for stimulating pulsatile growth hormone release, pairing a ghrelin agonist with a GHRH analog to raise IGF-1