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The efficacy of lorcaserin appears similar to that of orlistat (mean difference in weight loss between active and placebo treated groups approximately 3 to 4 kg) and perhaps slightly less than that of phentermine-topiramate

Older adults and vegetarians may benefit from a vitamin B12 supplement or an increased intake of foods fortified with vitamin B12

[5] In summary, pyridoxine may decrease the efficacy of certain medications (notably levodopa and some anticonvulsants), and various drugs can in turn precipitate vitamin B deficiency

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