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Ayyadevara S, Engle MR, Singh SP, Dandapat A, Lichti CF, Benes H, Shmookler Reis RJ, Liebau E, Zimniak P: Lifespan and stress resistance of Caenorhabditis elegans are increased by expression of glutathione transferases capable of metabolizing the lipid peroxidation product 4-hydroxynonenal

A 6-week clinical trial using fluoxetine as a positive control found that oral administration of CU at a dose of 1,000 mg/day produced effects comparable to those of 20 mg/day fluoxetine, with response rates on the 17-item Hamilton Depression Rating Scale (HAM-D17) exceeding 60% for both treatments, significantly outperforming placebo (12.5%51.8%) (Sanmukhani et al., 2014)