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1 Introduction Migraine manifests as a chronic neurovascular disease characterized by unilateral or bilateral throbbing severe headaches, predominantly unilateral, recurring with symptoms such as nausea, vomiting, photophobia, and phonophobia that impair autonomic nervous system functions (Steiner and Stovner, 2023) many sufferers cannot perform normal or work activities

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Aging Cell 21 , e13540 (2022)

213-220 (July-September 1982)

However, most delta-8 THC marketed in vapes or other products is synthetically produced because there is not enough in the plant naturally to extract it efficiently