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The mechanism is generally telogen effluvium driven by rapid weight loss rather than a direct effect of tirzepatide, similar to what is seen after bariatric surgery or any aggressive caloric deficit

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However, the liquid chromatography high-resolution mass spectrometry (LC-HRMS) analysis failed to identify a plasma metabolite that corresponds to a 7-HMG hydrolysis product with an expected m / z of 401.2071 (Figure S1)

This includes the initial consultation and the injection

Besides reducing appetite, tirzepatide may also improve sugar and fat metabolism