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Rare but serious adverse events, such as severe hepatotoxicity, pancreatitis, or moodrelated changes, necessitate prompt evaluation and discontinuation of therapy when identified

a cycloalkyl group is unsubstituted or substituted with one or more ring system substituents which may be the same or different, and are as defined within

Fecal elimination of metabolites also occurs, particularly following oral administration, though quantitative contribution of each elimination pathway varies by route and dose

This feature is particularly relevant because it contributes to its distinct pharmacological profile

They can be classified in the following macro-categories: cycloaddition reactions (Figures 4BD), thiol-based chemistry (Figure 4E), coupling reactions (Figure 4F), and imine chemistry (Figure 4G)

Fawcett JW, Asher RA