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This method is particularly effective for individuals with absorption issues, such as those with gastrointestinal disorders or older adults with decreased gastric acid production

In some cases deficiency is caused by an autoimmune disorder

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MacMillan CJ, Furlong SJ et al (2012) Bevacizumab diminishes experimental autoimmune encephalomyelitis by inhibiting spinal cord angiogenesis and reducing peripheral T-cell responses

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These patients may experience an increased likelihood of toxicity, particularly from Vitamin B6 or B12