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10.1016/j.mtbio.2025.101757 Summary Keywords myocardial ischemia, oxidative stress, ischemia-reperfusion injury, endogenous antioxidant defense, translational challenges, redox signaling, therapeutic strategies, precision medicine Citation Chen H, Tang Y, Ren P and Wu W (2025) The unmet promise: a critical review of antioxidant strategies in myocardial ischemia-reperfusion injury and the path towards precision medicine