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One of the main causes of decreased insulin secretion capacity in diabetes is oxidative stress

So temperature is a powerful stimulus, as we know, for biology

However, when the physiological demand for antioxidants surpasses their bioavailability, the brain enters a state of REDOX imbalance in which ROS accumulate, leading to neuronal damage [6, 7]

This targeted modulation allows beneficial aspects of inflammation to proceed while limiting chronic inflammation that impedes repair

Although these findings were observed in non-CRC models, they are highly relevant to CRC, where hypoxia-driven chemoresistance remains a significant challenge (141)