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Thilagarajah R, Witherow RO and Walker MM: Oral cimetidine gives effective symptom relief in painful bladder disease: A prospective, randomized, double-blind placebo-controlled trial

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(2) qualifying peer-reviewed literature for medical devices and that the medical device is used to deliver a therapy to reduce postoperative pain, or produce postsurgical or regional analgesia

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Many users report noticeable pain reduction within 3 to 7 days, with significant functional improvements appearing by weeks 2 to 3