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Here, we provide a comprehensive overview of the complex interplay between Mn metabolism and various diseases, integrating insights gleaned from environmental Mn toxicity, inherited Mn transportopathies, and their molecular mechanisms

Liu Y, Li X, Zhou X, Wang J, Ao X

Therefore, we designed a dual ferroptosis amplification strategy using an iron-based MOFs that combined iron supply and de novo GSH elimination for effective ferroptosis management

performed a metabolism study with bromfenac to scrutinize the formation of reactive intermediates and their linkage to the hepatotoxicity of this compound ( In vitro studies have revealed that bromfenac requires conjugation by UGTs to form a bromfenac glucuronide intermediate that cyclizes to a major metabolite, bromfenac indolinone (BI)

This has led to the concept of TDM, which involves quantifying drug concentrations and antibody levels to guide individualized dosing adjustments, thereby improving and maintaining long-term efficacy [295]

Interestingly, cytosolic roGFP2-Orp1 showed a potential oxidation after removal of TCEP ( Fig