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(-)-Epigallocatechin-3-gallate inhibits eNOS uncoupling and alleviates high glucose-induced dysfunction and apoptosis of human umbilical vein endothelial cells by PI3K/AKT/eNOS pathway

Notably, only the highest dose of BIO89-100 administered weekly appeared to elicit strong pharmacodynamic effects mediated via FGFR1c activity in adipose tissue, i.e., significantly increasing systemic levels of adiponectin