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Thus, selective c-Met inhibitors may be a better choice for treatment in patients and more studies are needed to identify the reason for phase II clinical trial failure and the feasibility of using c-Met targeting therapies

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Therefore, achieving the specific accumulation of drugs at tumor sites remains a key challenge, which necessitates the development of novel delivery systems such as responsive nanocarriers and antibody-drug conjugates

Potential therapeutic effects (based on animal and early human data): Enhances tendon, ligament, and muscle repair Promotes angiogenesis (formation of new blood vessels) Reduces inflammation and oxidative stress Protects gut mucosa and may aid in GI disorders (ulcers, leaky gut) May support neurological recovery and joint health Modulates nitric oxide and dopamine/serotonin pathways (possible mood, focus benefits) (Note: Most data are from preclinical studies

doi:10.3109/14756366.2010.526769