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The 2025 review in the International Journal of Molecular Sciences represents the most comprehensive English-language synthesis of this body of research to date

Increased expression levels of genes associated with autophagy, oxidative stress and inflammation were observed in copper-treated HepG2 ATP7B-KO cells and in primary hepatocytes from patients with WD

Therefore, extensive future research is needed to address these issues and improve the delivery and patient experience [151, 190]

Quinine (Sigma-Aldrich) was dissolved in the 20% alcohol solution, according to the experimental conditions

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Later findings varied substantially according to species, route, timing and experimental conditions