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However, the precise mechanisms of ferroptosis in CHD have not been fully elucidated, necessitating further in-depth mechanistic investigations and the development of more effective and safer clinical intervention strategies to ultimately improve patient outcomes

doi: 10.1093/rheumatology/keu318 87 LechMLorenzGKulkarniOPGrosserMOStigrotNDarisipudiMNet al

HK2 interacts with nuclear proteins such as Max, Sirt1, IWS1, CTR9, and Spin1, increasing chromatin accessibility to regulate gene expression

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In the CNS, Prdx2 has been shown to be expressed in neurons and its de-regulation has been associated with several neurodegenerative diseases such as AD and PD [56-59]