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The tragic outcome of the 1999 Jesse Gelsinger case, in which an adenoviral vector was used to treat ornithine transcarbamylase deficiency and resulted in a rapid onset of fever, clotting abnormalities, and fatal liver failure, highlighted the risks of this technology

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10.1016/s1472-6483(10)61590-8 Reprod

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Nevertheless, there are also reports of direct connection between BER and repair of platinum damage [32]

These rare cells hold the promise of novel therapeutics for degenerative diseases for which there are currently no cures or even effective treatments