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A 2025 Nature Communications paper mapped the binding to the disordered transactivation domain of p53, adding structural detail to how FOXO4-DRI engages its target

This is to be expected as these cells are already expressing hTERT mRNA, moreover, in the normal cells, epitalon would have to initiate hTERT expression, presumably by promoter activation

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Despite growing interest, it is not approved by regulatory agencies such as the FDA for human therapeutic use and remains strictly for laboratory research