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Throughout the FBS manufacturing process, challenges related to quality nonconformities, health safety, ethical concerns and negative environmental impacts have collectively driven the implementation of regulation governing the use of FBS in cell culturing (Liu et al., 2023

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Propionyl coenzyme A is further metabolized into a form that plays a role in the tricarboxylic acid cycle (TCA cycle) [1], which itself plays a key role in cellular aerobic respiration