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A vitamin B12 deficiency can develop slowly and symptoms may include: Persistent tiredness or low energy Shortness of breath Pale skin Pins and needles Memory or concentration difficulties If left untreated, deficiency can lead to more serious neurological complications

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Many RA patients will start to experience an improvement in symptoms after six to eight weeks on methotrexate, but it can take up to six months before you would reach the full benefits of taking the drug

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