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LCAC exposure has been reported to alter cardiac electrophysiological and arrhythmia susceptibility stereotypically (Figure 2, this includes reductions in the amplitude and duration of cardiac action potentials (APA and APD, respectively), as well as a decreased rate of depolarization (V max of phase 0) and, often, a depolarization of the resting membrane potential (RMP)

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In MCAS, mast cells become chronically unstable and hyper-reactive, degranulating in response to benign triggers like temperature changes, stress, or certain foods

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