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Polyphenols are also subject to various denaturing conditions (103), such as heat, light, oxygen, pH variations, and enzymatic degradation, which reduce their bioavailability and limit their efficacy as bioactive compounds (108)

Patients who have undergone gastrectomy or pancreatectomy may have impaired absorption of all fat-soluble vitamins, including vitamin A ( Liver diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD), are linked to altered vitamin A homeostasis, but it remains unclear whether a vitamin A deficit contributes to the pathogenic mechanisms that can progress from MASLD to HCC ( Retinoids have also been tested in the past as therapeutic agents for many cancer types, due to their ability to promote differentiation and potentially induce cancer cell death

Even a 5 year delay in progression would drastically reduce the number of people affected, saving the health care system billions and preserving the quality of life of affected individuals

adipose cells may also contribute to modulate appetite (Obradovic et al., 2021) also seems to affect appetite in fish (Chisada et al., 2014

We also demonstrated that this complete Ube3a deletion in MEFs affected the proliferation and apoptosis capacity of these cells [29, 30]

Cancer Cell 44(1):24-49, 2026