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Attempts to remove a substance from the whole organism may have the effect of increasing the burden present in one part of the organism

2.4 Determination of cell size and cell count Cell proliferation in culture was monitored using the CASY Cell Counter system (OMNI Life Science)

However, these inhibitors are not used clinically because they have a broad range of activity, high toxicity, and potential off-target effects, which complicate their therapeutic application

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Moreover, caffeine has been shown to inhibit chronic inflammation, its anti-inflammatory nature downregulates the pro-inflammatory cytokines and microglial activation, thereby protecting neuronal damage (156)

From a clinical perspective, functional imaging of hypoxia, redox imbalance, and acidosis is increasingly being explored as part of a precision oncology framework