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Yes, supplements like vitamin C, vitamin E, and glutathione support melanin regulation

Fogacci et al

Oxidized, heme-depleted Hb forms precipitates (Heinz bodies), which accumulate within the cells, resulting in membrane rigidity and decreased RBC deformability (151)

However, due to the large molecular size, topical glutathione may have limited skin penetration, though it can still support skin health when combined with other active ingredients like vitamin C, kojic acid, or niacinamide