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For instance, upregulation of the SSP is driven by the AMP-activated protein kinasemTORC1 axis, leading to elevated S-adenosylmethionine (SAM) production and increased expression of DNA methyltransferases, thereby promoting oncogenic transformation of primary pancreatic ductal epithelial cells ( In hepatocellular carcinoma (HCC), USP10 activates liver kinase B1 (LKB1) through deubiquitination

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Compared with the NG group, thyroid tissue exhibited varying degrees of enlargement in the Model, LT4, and WGM groups

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Moreover, ketone ester promoted a faster recovery from weight loss and reduced lung injury, resulting in improved overall survival (Extended Data Fig