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Description

Different strategies influence pro-inflammatory (M1) or anti-inflammatory/reparative (M2) macrophage phenotypes by modulating key metabolic enzymes, nutrient-sensing signals, or metabolite levels, and have shown certain therapeutic potential in a variety of inflammatory or autoimmune disease models

Cancer 1871 , 138159 (2019)

Liu, T., Mukosera, G

Broad suppression of this process may inadvertently impair the immune systems capacity to mount effective antitumor responses and diminish the overall efficacy of immunotherapy