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Not for patients seeking a quick mental edge

Neonatal Perinatal Med

KarXT is the first antipsychotic to target muscarinic cholinergic receptors rather than dopamine receptors: xanomeline selectively activates M1/M4 receptors, modulating acetylcholine, dopamine, and glutamate pathways implicated in schizophrenia, while peripherally restricted trospium reduces cholinergic adverse effects [131, 132]