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Given the many unknowns with high dose folic acid supplementation, particularly unmetabolized folic acid (as covered in my folate article), Im not able to draw any strong conclusions here

That being said, it may cause severe side effects if an allergy is present or if the individual is also taking certain medications

This creates a vicious cycle: the body desperately needs more B12 to repair virally damaged tissues and mount an immune response, but the gastrointestinal system is too inflamed and dysregulated to absorb the vitamin efficiently from standard food sources