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However, due to B12s effect on the metabolism, it is possible that B12 deficiency could play some part in weight gain, to whatever degree

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AOD-9604 Metabolic Curr Opin Investig Drugs, 2004, clinical-development review covering Phase 2 obesity trials PMID 16931496 Jensen MD

Many people who suffer from brain fog may be dealing with underlying nutrient deficiencies, including low levels of B12

Why It Pairs So Well With GLP-1 Agonists GLP-1 agonists like Retatrutide create a caloric deficit through multiple routes: appetite suppression, slowed gastric emptying, and (in Reta's case) glucagon receptor agonism that drives additional energy expenditure