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96 ChenY.TassoneF.BermanR

Nature 358(6381):1516

Specifically, Prevotella copri produces succinic acid, which binds to succinate receptors on dendritic cells, enhancing antigen-specific T cell responses and contributing to host immune defense mechanisms (Dan et al., 2020)

however, in sarcopenia, inflammation reduces muscle tissues ability to grow in response to insulin

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Despite these advances, translation into clinical practice remains limited due to challenges such as immunogenicity, systemic instability, manufacturing scalability, and regulatory complexity