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[] Furthermore, mtDNA 6mA does not function in isolation but may engage in cross talk with other mitoepigenetics and nuclear epigenetic marks, including 5mC and 5-hydroxymethylcytosine (5hmC), particularly under stress conditions

Recent studies have highlighted the role of exosome circRNAs and lncRNAs in mediating cell-to-cell communication within the tumor microenvironment, further underscoring their potential as biomarkers and therapeutic targets in cancer (67)

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Therefore, Y1003 mutations in the cbl-binding region can lead to the continued activation of Met and its downstream signaling pathways, and even induce cancer