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In addition to natural aging, environmental causes include: Chronic exposure to chemical toxins Cadmium exposure Alcohol use Smoking Pollution Poor diet (Standard American Diet (SAD)) Stress Certain medications (Tylenol) UV radiation exposure Certain illnesses are known to decrease glutathione levels

A study by Campbell et al

Pretreatment with curcumin also lead to a significant increase in the activities of superoxide dismutase, catalase, and glutathione peroxidase after gamma-irradiation [23]

- **Modifiers**: Use JW (drug waste) or JZ (no waste) modifiers as required by CMS when billing for single-use vials

Graham DL, Eccleston JF, Chung CW, Lowe PN (1999) Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins

Folate, vitamin B12, one carbon metabolism and the nervous system: Excess folic acid is potentially harmful