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The liver is a target for metabolism in the fish body, and liver biomarkers are useful as indicators of the general health of fish and are considered to reflect physiological exposure to a variety of redox factors (Sadekarpawar and Parikh 2013)

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The treatment with the specific SIRT1 activator BF175 in diabetic pod-HIV mice can effectively alleviate albuminuria and glomerular lesions ( Additionally, the activation of the SIRT1/peroxisome proliferator-activated receptor coactivator-1 (PGC-1) pathway attenuates RTECs injury in the RIRI mice model ( Hypertensive nephropathy

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