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S-adenosyl-l-methionine (SAM) reactions: SAM, a derivative of methionine, is involved in the synthesis of epinephrine , choline, and other substances, and is an important methyl donor (see above)

Oxidative stress and antioxidant studies

Food and Chemical Toxicology 45(12):24412445 Tchekalarova J, Kubov H, Mare P (2007) Effects of postnatal caffeine exposure on seizure susceptibility in developing rats

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National Institutes of Health, 2015)

[89] collected urine samples over a 24-hr period and found at rest there was no significant change in urine output at rest when consuming water or varying doses of caffeine in the range of 114 mg/d-253 mg/d (1.4 mg/kg - 3.13 mg/kg)