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These opposing effects highlight how the net impact of the crosstalk on radiosensitivity is determined by specific molecular contexts, presenting both a challenge and an opportunity for personalized radiosensitization strategies

L-carnitine primarily helps transport fatty acids into mitochondria for energy production

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Additionally, luteolin exhibits anti-inflammatory effects by inhibiting significant inflammatory pathways, particularly NF-B and PI3K/Akt/mTOR, which play vital roles in pulmonary inflammation [228, 229]

This effect of hesperidin is probably mediated by the inhibition of the L-arginine-nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) pathway and by increasing BDNF levels in the hippocampus