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For serum preparation, blood samples were incubated for 1 h at room temperature and then centrifuged (1,950 x g, 15 min, Varifuge 3.0, Heraeus, Hanau, Germany) and stored at -80C prior to further analysis

In a multivariate analysis, upregulation of LRP8 was the strongest risk factor for CNS relapse (OR 5.2, p=0.004), demonstrating greater impact than classical risk factors of CNS disease (age, MRD status and white blood cell counts (WBC)) ( Figure 5G )

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Upon activation, TRPM2 mediates calcium influx, which is crucial for several signaling pathways

The expanding role of NADPH oxidases in health and disease: no longer just agents of death and destruction

The companies have not yet completed clinical trials of the booster in younger children