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Description

Hypoxia increases the deoxycytidine triphosphate (dCTP) level through the pentose phosphate pathway (PPP) via glucose metabolism and results in resistance to gemcitabine, a dCTP analog 87

Breaking plateaus often requires addressing factors beyond peptide dosing

Recently, the discovery of reversible/irreversible covalent inhibitors targeting cysteine residues in and around the ATP-binding pocket of kinases has been gaining considerable attention (94)