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At the end of the second cycle of treatment and after 28 months of multimodal treatment, the patient underwent follow-up with physical examination and penile Doppler ultrasound

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In the absence of amino acids such as cystine, cells promote translation of ATF4 via the general control non-repressor 2 (GCN2) -eukaryotic initiation factor (eIF2a) signaling pathway, which promotes transcription of genes involved in amino acid metabolism and stress response, including SLC7A11, enabling cells to cope with amino acid starvation

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