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This attrition is what scientists call the Hayflick limit, named after Leonard Hayflick, who discovered that normal human cells divide roughly 4060 times before stopping [23]

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Enhancing mitophagy (e.g., via urolithin A or nicotinamide riboside) reduces mtDNA burden and inflammation in preclinical models [151]

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This is why lyophilized (freeze-dried) powder is inherently more stable than a pre-mixed solution: removing water removes the hydrolysis substrate

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& Groden, J

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