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This metabolic rewiring supports nitric oxide (NO) synthesis via inducible nitric oxide synthase (iNOS), drives the accumulation of reactive oxygen species (ROS), and fuels the production of pro-inflammatory cytokines

Thus, neither estrogen alone nor estrogen plus progesterone can sustain breast development without other mediators, such as GH and IGF-1

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Start with doses lower than what studies use if you're sensitive