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This ROS overproduction, compounded by elevated iron levels, enhances lipid peroxidation, a key feature of ferroptosis

The complexes I and III of mitochondrial ETC produces superoxide anion (Rodriguez and Redman, 2005)

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2 DNA methylation and tumor 2.1 Process and mechanism of DNA methylation In a broad sense, DNA methylation refers to the chemical modification of methyl binding to a specific base on DNA through a covalent bond, which may occur at the C-5 position of cytosine, N-6 position of adenine, and N-7 position of guanine (Ahmad and Rao, 1996)