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Glutaminase: a hot spot for regulation of cancer cell metabolism

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doi: 10.1007/s00281-019-00741-8 199 ReinckeSMvon WardenburgNHomeyerMAKornauHCSpagniGLiLYet al

The dual agonist mechanism provides robust glycemic control and significant weight reduction, with clinical trials demonstrating A1C reductions of 1.92.4% and weight loss of approximately 1522% of body weight in non-diabetic adults with obesity (SURMOUNT-1 trial), with more modest weight loss typically observed in patients with type 2 diabetes

Epigenetic silencing of NAD(P)H:quinone oxidoreductase 1 by hepatitis B virus X protein increases mitochondrial injury and cellular susceptibility to oxidative stress in hepatoma cells

In a rodent model of liver ischemia-reperfusion, TRF for 810 h during the active phase, compared to 24 h food access, improved tissue regeneration, reduced pro-inflammatory (like IL-6) and augmented anti-inflammatory (like IL-10) markers, prevented ROS production and increased systemic -hydroxybutyrate (BHB) (Ren et al., 2019)