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Among these, the inflammatory cascade is particularly notable as a central mechanism exacerbating cerebral IRI [105, 106]

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Additionally, celecoxib, a selective COX-2 inhibitor used in treating inflammation in SLE, has been shown to upregulate SR-B2 and downregulate SR-E1 in macrophagesindicating that prostaglandin pathways can modulate SR expression and potentially influence inflammatory outcomes (119)

[DOI] [PubMed] [Google Scholar] 355

doi: 10.1016/j.bbamcr.2018.02.010 56 ZhanMWangHXuSWYangLHChenWZhaoSXet al

Mechanisms of renal apoptosis in health and disease