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Refrigeration provides a crucial secondary line of defense

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It is important to state that two separate folate cycles coexist in the cell, one in the cytosol and one in the mitochondria with different isoforms of 5,10-methylene-THF dehydrogenases (MTFHR) (Figure 2)

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This is because orforglipron is a small molecule absorbed through passive diffusion in the small intestine, rather than a peptide requiring the SNAC absorption enhancer and stomach-specific absorption conditions needed by Rybelsus