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Ethics statement Ethical approval was not required for the studies on humans in accordance with the local legislation and institutional requirements because only commercially available established cell lines were used

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To address this issue, we evaluated a potential triple combination therapy, comprising two metabolic-targeting drug and a chemotherapeutic agent, aiming to develop a more effective therapeutic approach for MNA NB

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As a border collie mix, Yuki may also have been a carrier for intestinal cobalamin (B12) malabsorption, the genetic mutation originally found in border collies

This ensured the central assessors had no information linking the images to a specific treatment allocation