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Respirology 23(4):359368

Increased TMAO levels in addition to endothelial dysfunction, vascular aging, and oxidative stresses have been shown to cause thrombotic events and platelet excitability in humans, which in turn induce atherosclerosis [69, 72]

Nevertheless, transcriptional modifications may also lead to delays in recovery, as ongoing perturbations on a transcriptional level were observed for up to 6 months after infection, with PASC patients showing a distinct profile, such as upregulation of the alarmins S100A8 and HMGB1, mediators and markers of innate immune activation (124)

Infection complicated by obstruction is a medical emergency that requires placement of a drainage device (Curhan 2012)