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Metastatic or primary lung tumours were shown to rely on enhanced expression of NFS1 to maintain the supply of FeS clusters as co-factors of multiple essential proteins and enzymes in the cell that are exposed to (damaging) high oxygen concentrations

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PMID: 166 ZhangYLiCZhangWZhengXChenX

Sphingomyelin accumulation occurs in Niemann-Pick diseases (NPD) type A and B and causes severe disturbance in cell homeostasis [75]

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Originally native to Southern Europe, the Mediterranean region, Western Asia and North Africa, Silybum marianum is today found worldwide including in North and South America and Southern Australia