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Contribution of relapse-independent progression versus relapse-associated worsening to overall confirmed disability accumulation in typical relapsing multiple sclerosis in a pooled analysis of 2 randomized clinical trials

OrtegaHLemiereCLlanosJPForshagMPriceRAlbersFet alOutcomes following mepolizumab treatment discontinuation: real-world experience from an open-label trial

The resulting lactate upregulates SRSF10 via H3K18la, eventually forming a feedback loop involving circMETTL3/METTL3-156aa/LDHA/Lactate/SRSF10 that triggers cytokine storms in sHLH