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Oxidative stress is a major driver of ferroptosis, with excessive MitoROS accumulation leading to lipid peroxidation and the exacerbation of IDD

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Additional evidence supports the association of certain GPX isoforms, such as GPX2, with abiotic stress and developmental processes

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Hu H, Lin A, Kong M, Yao X, Yin M, Xia H, et al

In patients with mild cognitive impairment (often a precursor to Alzheimers disease), prolonged melatonin supplementation reportedly slowed the progression of cognitive decline and improved sleep and mood, though larger trials are needed