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J Pharm Sci 86(3):378383 Sugibayashi K, Hayashi T, Morimoto Y (1999) Simultaneous transport and metabolism of ethyl nicotinate in hairless rat skin after its topical application: the effect of enzyme distribution in skin

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Toxicity and side effects B12 is considered relatively safe because the body does not store high amounts meaning that it doesn't build up to high enough levels to cause toxic problems