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At 0.5 mg/kg, the highest dose tested, two subjects experienced serious adverse events (SAEs) of stomatitis, a known side-effect of rapamycin 17

This could introduce challenges for patients with lifelong anticoagulation needs, such as those with heart failure and atrial fibrillation (Yasueda et al., 2016) and could interact with antihypertensive drugs to cause an excessive drop in blood pressure, necessitating careful monitoring and dose adjustments (Zhao et al., 2022)

RNA sequencing RNA from cells were extracted using the RNA isolater Reagent (Vazyme, China) according to the manufacturers protocol

In HFD-fed fish, a significant consequence was the downregulation of cpt-1 , acox-1 , and ppar , leading to reduced -oxidation [47]

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